Alpha-lipoic acid (ALA), also known as thioctic acid, is a molecule that has confirmed over time its antioxidant properties, as well as properties in the treatment of DIABETIC NEUROPATHY with a daily dosage of 2×300 mg, only in case of a retard formulation.
Several studies on patients with DIABETIC NEUROPATHY have shown that ALA is able to significantly reduce pain and paresthesia.
Alpha-lipoic acid (ALA), however, has a limit in BIOAVAILABILITY because the molecule is characterized by a very short biologic half-life (between one and two hours), which determines a decrease in the concentration of the active in a short time, meaning that not all the active substance that is taken is absorbed and then used by the body.
Such problem is overcome in the formulation of ALA CRONO COMPLEX thanks to the patented MATRIS which guarantees the absorption of more than 85% over a period of 9 hours.
Therefore, with the administration of two capsules there is certainly an optimal daily coverage.
The patent allows to obtain microdoses of the active in microspheres with a diameter of 1000- 1400 pm that are uniformly distributable throughout the gastro-intestinal mucosa; to protect substances from a short biologic half-life, and from first pass effect, thus ensuring absorption optimization through a complete release in about 8 hours.
In order to demonstrate the concept, two graphs below are compared, the one on the left describes the absorption of ALA CRONO COMPLEX while the right column describes the bioavailability of the alpha-lipoic acid molecule (ALA) in a random competitor.
In general, the biologic half-life of alpha-lipoic acid (ALA) is about an hour.
ALA CRONO COMPLEX MATRIS is rapidly absorbed and reaches significant plasma concentrations.
The kinetic variations obtained through MATRIS technology have a significant influence on the quality of the product.
The best bioavailability of ALA that is obtained makes ALA CRONO COMPLEX a better “antioxidant” strategy in the indications for which it is intended to be used for.
To complete the formula of ALA CRONO COMPLEX there is Nervonic acid which is essential for the biosynthesis of the myelinic sheath of nerve cells, Vitamins of B group B (B3, B6, B12) for a good functioning of the nervous system and Vitamin E which contributes to the protection of cells from oxidative stress.
|INGREDIENTIS||Daily value for max dose (2 cps)||%NVR*|
|Alpha Lipoic Acid||600mg||-|
|Dry blueberry extract titrated|
to 25% anthocyanoside
|of which anthocyanoside||25mg||-|
|Niacin (Vit. B3)||18mg||33%|